Here's the description for episode 4
 
“The Big Empty” — (8:00-9:00 p.m. ET) (TV-14, LV) (HDTV)

THE LONG WAY HOME – When multiple patients of grief counselor Mia Vallens (guest star Rukiya Bernard) turn up dead, Sam (Jared Padalecki), Dean (Jensen Ackles) and Jack (Alexander Calvert) investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own. John Badham directed the episode written by Meredith Glynn (#1304). Original airdate 11/2/2017.
 
So, this is apparently not about The Empty, in spite of the tease of the title. Instead we are going to get a study of grief, which is an interesting idea. What do you think? Let us know in the comments or the discussion thread for episode 4.